Evaluating the impact of age on immune checkpoint therapy biomarkers

Evaluating the impact of age on immune checkpoint therapy biomarkers

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Summary: Both tumors and aging alter the immune landscape of tissues. These interactions may play an important role in tumor progression among elderly patients and may suggest considerations for patient care. We leverage large-scale genomic and clinical databases to perform comprehensive comparative...

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Bibliographic Details
Main Authors: Rossin Erbe, Zheyu Wang, Sharon Wu, Joanne Xiu, Neeha Zaidi, Jennifer La, David Tuck, Nathanael Fillmore, Nicolas A. Giraldo, Michael Topper, Stephen Baylin, Marc Lippman, Claudine Isaacs, Reva Basho, Ilya Serebriiskii, Heinz-Josef Lenz, Igor Astsaturov, John Marshall, Josephine Taverna, Jerry Lee, Elizabeth M. Jaffee, Evanthia T. Roussos Torres, Ashani Weeraratna, Hariharan Easwaran, Elana J. Fertig
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
cancer
aging
immune
TCGA
immunotherapy
genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721010378

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http://www.sciencedirect.com/science/article/pii/S2211124721010378

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