Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action

Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action

Whooping cough is a severe childhood disease, caused by the bacterium <i>Bordetella pertussis</i>, which releases pertussis toxin (PT) as a major virulence factor. Previously, we identified the human antimicrobial peptides α-defensin-1 and -5 as inhibitors of PT and demonstrated their ca...

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Bibliographic Details
Main Authors: Carolin Kling, Anja Sommer, Yasser Almeida-Hernandez, Armando Rodríguez, Julio A. Perez-Erviti, Rajendra Bhadane, Ludger Ständker, Sebastian Wiese, Holger Barth, Mario Pupo-Meriño, Arto T. Pulliainen, Elsa Sánchez-García, Katharina Ernst
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
pertussis toxin
defensins
bacterial AB-type toxin
human peptide
antimicrobial peptide
toxin inhibitor
Online Access:https://www.mdpi.com/1422-0067/24/13/10557

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https://www.mdpi.com/1422-0067/24/13/10557

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