Theoretical Characterization of the Step-by-Step Mechanism of Conversion of Leukotriene A<sub>4</sub> to Leukotriene B<sub>4</sub> Catalysed by the Enzyme Leukotriene A<sub>4</sub> Hydrolase

Theoretical Characterization of the Step-by-Step Mechanism of Conversion of Leukotriene A<sub>4</sub> to Leukotriene B<sub>4</sub> Catalysed by the Enzyme Leukotriene A<sub>4</sub> Hydrolase

LTA<sub>4</sub>H is a bifunctional zinc metalloenzyme that converts leukotriene A<sub>4</sub> (LTA<sub>4</sub>) into leukotriene B<sub>4</sub> (LTB<sub>4</sub>), one of the most potent chemotactic agents involved in acute and chronic inflam...

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Bibliographic Details
Main Authors: Miquel Canyelles-Niño, Àngels González-Lafont, José M. Lluch
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
leukotriens
leukotriene A<sub>4</sub> hydrolase
enzyme catalysis
QM/MM calculations
molecular dynamics simulations
proinflammatory lipid mediators
Online Access:https://www.mdpi.com/1422-0067/23/6/3140

Internet

https://www.mdpi.com/1422-0067/23/6/3140

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