Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor.

Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor.

The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics. While human and mouse CAR feature a high basal activity and low...

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Bibliographic Details
Main Authors: Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn, Leszek Wojnowski, Björn Windshügel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4010427?pdf=render

Internet

http://europepmc.org/articles/PMC4010427?pdf=render

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