Hydroxychloroquine can impair tumor response to anti-PD1 in subcutaneous mouse models

Summary: Hydroxychloroquine (HCQ) is a well-known anti-inflammatory drug but is also known as an anti-inflammatory drug. Here, we evaluate the influence of HCQ treatment on the effect of anti-PD1 tumor immunotherapy. Anti-PD1 therapy-sensitive tumor lines MC38, CT26, and RIL-175 were used to investi...

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Bibliographic Details
Main Authors: Simon Wabitsch, John C. McVey, Chi Ma, Benjamin Ruf, Olena Kamenyeva, Justin D. McCallen, Laurence P. Diggs, Bernd Heinrich, Tim F. Greten
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220311871