Cerebrospinal Fluid Cell-Free DNA-Based Detection of High Level of Genomic Instability Is Associated With Poor Prognosis in NSCLC Patients With Leptomeningeal Metastases

Cerebrospinal Fluid Cell-Free DNA-Based Detection of High Level of Genomic Instability Is Associated With Poor Prognosis in NSCLC Patients With Leptomeningeal Metastases

IntroductionLeptomeningeal metastasis (LM) commonly occurs in non-small cell lung cancer (NSCLC) patients and has a poor prognosis. Due to limited access to leptomeningeal lesions, the genetic characteristics of LM have not been explored to date. Cerebrospinal fluid (CSF) may be the most representat...

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Bibliographic Details
Main Authors: Xi Wu, Puyuan Xing, Min Shi, Weihua Guo, Fangping Zhao, Honglin Zhu, Jianping Xiao, Jinghai Wan, Junling Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
cerebrospinal fluid cfDNA
leptomeningeal metastases
EGFR-TKI resistance
genomic instability
NSCLC
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.664420/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.664420/full

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