Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages.

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages.

The fungal pathogen Histoplasma capsulatum (Hc) invades, replicates within, and destroys macrophages. To interrogate the molecular mechanisms underlying this interaction, we conducted a host-directed CRISPR-Cas9 screen and identified 361 genes that modify macrophage susceptibility to Hc infection, g...

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Bibliographic Details
Main Authors: Allison Cohen, Edwin E Jeng, Mark Voorhies, Jane Symington, Nebat Ali, Rosa A Rodriguez, Michael C Bassik, Anita Sil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010237

Internet

https://doi.org/10.1371/journal.ppat.1010237

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