STING suppresses bone cancer pain via immune and neuronal modulation

STING suppresses bone cancer pain via immune and neuronal modulation

There is an unmet clinical need to develop therapies to alleviate metastatic bone pain, frequently observed in patients with advanced cancers. Here, using mouse models of bone cancer pain, the authors show that STING agonists not only suppress bone cancer tumor burden, but also attenuate bone pain a...

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Bibliographic Details
Main Authors: Kaiyuan Wang, Christopher R. Donnelly, Changyu Jiang, Yihan Liao, Xin Luo, Xueshu Tao, Sangsu Bang, Aidan McGinnis, Michael Lee, Matthew J. Hilton, Ru-Rong Ji
Format: Article
Language:English
Published: Nature Portfolio 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24867-2

Internet

https://doi.org/10.1038/s41467-021-24867-2

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