RNA interference of argininosuccinate synthetase restores sensitivity to recombinant arginine deiminase (rADI) in resistant cancer cells

RNA interference of argininosuccinate synthetase restores sensitivity to recombinant arginine deiminase (rADI) in resistant cancer cells

<p>Abstract</p> <p>Background</p> <p>Sensitivity of cancer cells to recombinant arginine deiminase (rADI) depends on expression of argininosuccinate synthetase (AS), a rate-limiting enzyme in synthesis of arginine from citrulline. To understand the efficiency of RNA int...

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Bibliographic Details
Main Authors: Yo Hao-Hsin, Chang Yuan-Chen, Liang Yu-Fen, Wu Fe-Lin, Wei Ming-Feng, Shen Li-Jiuan
Format: Article
Language:English
Published: BMC 2011-04-01
Series:Journal of Biomedical Science
Subjects:
argininosuccinate synthetase
arginine deiminase
resistance
RNA interference
Online Access:http://www.jbiomedsci.com/content/18/1/25

Internet

http://www.jbiomedsci.com/content/18/1/25

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