Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms

Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms

Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic β cells. Further, patients with T1D have 3–4-fold increased risk of developing micro- and macrovascular complications. However, the contribution of immune-related factors cont...

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Bibliographic Details
Main Authors: Magdalena Keindl, Olena Fedotkina, Elsa du Plessis, Ruchi Jain, Brith Bergum, Troels Mygind Jensen, Cathrine Laustrup Møller, Henrik Falhammar, Thomas Nyström, Sergiu-Bogdan Catrina, Gun Jörneskog, Leif Groop, Mats Eliasson, Björn Eliasson, Kerstin Brismar, Peter M. Nilsson, Tore Julsrud Berg, Silke Appel, Valeriya Lyssenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Endocrinology
Subjects:
cardiovascular disease
Cluster of Differentiation 25 (CD25)
diabetes complications
nephropathy
regulatory T cells
retinopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.575469/full

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https://www.frontiersin.org/articles/10.3389/fendo.2020.575469/full

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