Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity

Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity

We evaluated the bioavailability, liver distribution, and efficacy of silymarin-D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) solid dispersion (silymarin-SD) in rats with acetaminophen-induced hepatotoxicity (APAP) compared with silymarin alone. The solubility of silybin, the major and ac...

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Bibliographic Details
Main Authors: Im-Sook Song, So-Jeong Nam, Ji-Hyeon Jeon, Soo-Jin Park, Min-Koo Choi
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
silymarin
D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS)
liver distribution
acetaminophen-induced hepatotoxicity
Online Access:https://www.mdpi.com/1999-4923/13/5/628

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https://www.mdpi.com/1999-4923/13/5/628

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