Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men

Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men

Summary: Lack of interleukin-6 (IL-6) leads to expansion of adipose tissue mass in rodents and humans. The exact underlying mechanisms have not been identified. In this placebo-controlled, non-randomized, participant-blinded crossover study, we use the IL-6 receptor antibody tocilizumab to investiga...

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Bibliographic Details
Main Authors: Beckey Trinh, Merel Peletier, Casper Simonsen, Peter Plomgaard, Kristian Karstoft, Bente Klarlund Pedersen, Gerrit van Hall, Helga Ellingsgaard
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports Medicine
Subjects:
Interleukin-6
tocilizumab
IL-6 receptor
obesity
exercise
metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121002548

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http://www.sciencedirect.com/science/article/pii/S2666379121002548

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