Sarbecovirus ORF6 proteins hamper induction of interferon signaling

Sarbecovirus ORF6 proteins hamper induction of interferon signaling

Summary: The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other betacoronaviruses. Here we show that ORF6 inhibits induction of innate immune signaling, including upregulation of type I interferon (IFN) upo...

Full description

Bibliographic Details
Main Authors: Izumi Kimura, Yoriyuki Konno, Keiya Uriu, Kristina Hopfensperger, Daniel Sauter, So Nakagawa, Kei Sato
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
SARS-CoV-2
COVID-19
ORF6
type I interferon
type III interferon
interferon-stimulated gene
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002308

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721002308

Similar Items