Insights into the regulation of TNF-a production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition

Insights into the regulation of TNF-a production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition

OBJECTIVE: The objective of this study was to determine the effect of nonspecific phosphodiesterase inhibition on transcription factor activation and tumor necrosis factor-alpha (TNF-a) production in lipopolysaccharide (LPS)-stimulated human mononuclear cells. INTRODUCTION: The production of TNF-a f...

Full description

Bibliographic Details
Main Authors: Jessica Deree, Joilson O. Martins, Heidi Melbostad, William H. Loomis, Raul Coimbra
Format: Article
Language:English
Published: Elsevier España 2008-01-01
Series:Clinics
Subjects:
Sepsis
Pentoxifylline
Cyclic adenosine-3
5-monophosphate (cAMP)
cAMP-response element binding protein (CREB)
Nuclear factor-kB (NF-kB)
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000300006

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000300006

Similar Items