Transcriptional profiling upon T cell stimulation reveals down-regulation of inflammatory pathways in T and B cells in SLE versus Sjögren’s syndrome

Transcriptional profiling upon T cell stimulation reveals down-regulation of inflammatory pathways in T and B cells in SLE versus Sjögren’s syndrome

Abstract Systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) share clinical as well as pathogenic similarities. Although previous studies suggest various abnormalities in different immune cell compartments, dedicated cell-type specific transcriptomic signatures are often masked b...

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Bibliographic Details
Main Authors: Gino Kwon, Annika Wiedemann, Lisa M. Steinheuer, Ana-Luisa Stefanski, Franziska Szelinski, Tomas Racek, Andreas Philipp Frei, Klas Hatje, Tony Kam-Thong, David Schubert, Thomas Schindler, Thomas Dörner, Kevin Thurley
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-023-00319-z

Internet

https://doi.org/10.1038/s41540-023-00319-z

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