Long read sequencing reveals poxvirus evolution through rapid homogenization of gene arrays

Long read sequencing reveals poxvirus evolution through rapid homogenization of gene arrays

Poxvirus adaptation can involve combinations of recombination-driven gene copy number variation and beneficial single nucleotide variants (SNVs) at the same loci. How these distinct mechanisms of genetic diversification might simultaneously facilitate adaptation to host immune defenses is unknown. W...

Full description

Bibliographic Details
Main Authors: Thomas A Sasani, Kelsey R Cone, Aaron R Quinlan, Nels C Elde
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
poxvirus
experimental evolution
gene conversion
long read sequencing
copy number variation
vaccinia virus
Online Access:https://elifesciences.org/articles/35453

Internet

https://elifesciences.org/articles/35453

Similar Items