Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications

Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications

The cellular level of TDP-43 (also known as TARDBP) is tightly regulated; increases or decreases in TDP-43 have deleterious effects in cells. The predominant mechanism responsible for the regulation of the level of TDP-43 is an autoregulatory negative feedback loop. In this study, we identified an i...

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Bibliographic Details
Main Authors: Miriam Pacetti, Laura De Conti, Luciano E. Marasco, Maurizio Romano, Mohammad M. Rashid, Martina Nubiè, Francisco E. Baralle, Marco Baralle
Format: Article
Language:English
Published: The Company of Biologists 2022-04-01
Series:Disease Models & Mechanisms
Subjects:
amyotrophic lateral sclerosis
epigenetics
tdp-43
tardbp
rna-binding proteins
aggregation
rna
Online Access:http://dmm.biologists.org/content/15/4/dmm049032

Internet

http://dmm.biologists.org/content/15/4/dmm049032

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