Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications

Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications

The cellular level of TDP-43 (also known as TARDBP) is tightly regulated; increases or decreases in TDP-43 have deleterious effects in cells. The predominant mechanism responsible for the regulation of the level of TDP-43 is an autoregulatory negative feedback loop. In this study, we identified an i...

Full description

Bibliographic Details
Main Authors:	Miriam Pacetti, Laura De Conti, Luciano E. Marasco, Maurizio Romano, Mohammad M. Rashid, Martina Nubiè, Francisco E. Baralle, Marco Baralle
Format:	Article
Language:	English
Published:	The Company of Biologists 2022-04-01
Series:	Disease Models & Mechanisms
Subjects:	amyotrophic lateral sclerosis epigenetics tdp-43 tardbp rna-binding proteins aggregation rna
Online Access:	http://dmm.biologists.org/content/15/4/dmm049032

Similar Items

Transcriptomic Analysis of Zebrafish TDP-43 Transgenic Lines
by: Alexandra Lissouba, et al.
Published: (2018-12-01)

TDP-43 Pathology in Alzheimer’s Disease
by: Axel Meneses, et al.
Published: (2021-12-01)

Robustness and Vulnerability of the Autoregulatory System That Maintains Nuclear TDP-43 Levels: A Trade-off Hypothesis for ALS Pathology Based on in Silico Data
by: Akihiro Sugai, et al.
Published: (2018-02-01)

Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation
by: N. Kreiter, et al.
Published: (2018-07-01)

A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS
by: Marc Shenouda, et al.
Published: (2022-06-01)

Epigenetic regulation of TDP-43: potential implications for amyotrophic lateral sclerosis
by: D. Y. Mengistu, et al.
Published: (2025-02-01)

TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis
by: Yuting Ren, et al.
Published: (2021-06-01)

Altered TDP-43 Structure and Function: Key Insights into Aberrant RNA, Mitochondrial, and Cellular and Systemic Metabolism in Amyotrophic Lateral Sclerosis
by: Leanne Jiang, et al.
Published: (2022-07-01)

ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration
by: Seiji Watanabe, et al.
Published: (2020-01-01)

TDP-43 pathology is sufficient to drive axon initial segment plasticity and hyperexcitability of spinal motoneurones in vivo in the TDP43-ΔNLS model of Amyotrophic Lateral Sclerosis
by: Svetlana Djukic, et al.
Published: (2025-02-01)

A panel of TDP-43-regulated splicing events verifies loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue
by: Maize C. Cao, et al.
Published: (2023-09-01)

TDP-43 expression influences amyloidβ plaque deposition and tau aggregation
by: Stephani A. Davis, et al.
Published: (2017-07-01)

To Be or Not To Be…Toxic—Is RNA Association With TDP-43 Complexes Deleterious or Protective in Neurodegeneration?
by: Suvithanandhini Loganathan, et al.
Published: (2020-01-01)

Low T-cell reactivity to TDP-43 peptides in ALS
by: Swetha Ramachandran, et al.
Published: (2023-07-01)

The Regulatory Role of RNA Metabolism Regulator TDP-43 in Human Cancer
by: Xueyou Ma, et al.
Published: (2021-10-01)

Cytoplasmic Human TDP-43 Mislocalization Induces Widespread Dendritic Spine Loss in Mouse Upper Motor Neurons
by: Marcus S. Dyer, et al.
Published: (2021-06-01)

c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation
by: Saebom Lee, et al.
Published: (2022-12-01)

Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo
by: Charlton G. Otte, et al.
Published: (2020-12-01)

Advancements in TDP-43 research: Towards biomarkers and therapeutic targets for amyotrophic lateral sclerosis
by: Yuhan Wu, et al.
Published: (2025-03-01)

TDP-43 Cytoplasmic Translocation in the Skin Fibroblasts of ALS Patients
by: Miguel A. Rubio, et al.
Published: (2022-01-01)

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons
by: Fabiola Rojas, et al.
Published: (2023-07-01)

CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation
by: Vivian I. Ko, et al.
Published: (2024-06-01)

Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology
by: Eric N Anderson, et al.
Published: (2021-06-01)

TDP-43 Proteinopathy Specific Biomarker Development
by: Isabell Cordts, et al.
Published: (2023-02-01)

Liquid–Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation
by: Donya Pakravan, et al.
Published: (2021-04-01)

Distinct Phospho-TDP-43 brain distribution in two cases of FTD, one associated with ALS
by: Álvaro C.B. Guedes, et al.

Validation of a newly developed immunoassay for TDP-43 in human plasma
by: Sayo Matsuura, et al.
Published: (2024-01-01)

Heterogeneity of cortical pTDP-43 inclusion morphologies in amyotrophic lateral sclerosis
by: Rachel H. Tan, et al.
Published: (2023-11-01)

Cyclin F can alter the turnover of TDP-43
by: Stephanie L. Rayner, et al.
Published: (2024-03-01)

The role of TDP-43 protein in amyotrophic lateral sclerosis
by: Piotr Włodarczyk, et al.
Published: (2022-12-01)

The effect of pH alterations on TDP-43 in a cellular model of amyotrophic lateral sclerosis
by: Yara Al Ojaimi, et al.
Published: (2024-07-01)

Identification of Genetic Modifiers of TDP-43: Inflammatory Activation of Astrocytes for Neuroinflammation
by: Jae-Hong Kim, et al.
Published: (2021-03-01)

TDP-43 dysfunction leads to bioenergetic failure and lipid metabolic rewiring in human cells
by: Miriam Ceron-Codorniu, et al.
Published: (2024-09-01)

An Amyloid-like Pathological Conformation of TDP-43 is Stabilized by Hypercooperative Hydrogen Bonds
by: Miguel Mompeán, et al.
Published: (2016-11-01)

Cytoplasmic TDP43 Binds microRNAs: New Disease Targets in Amyotrophic Lateral Sclerosis
by: Ximena Paez-Colasante, et al.
Published: (2020-05-01)

ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice
by: Mai Horiuchi, et al.
Published: (2024-11-01)

TDP-43 regulates endogenous retrovirus-K viral protein accumulation
by: Mamneet Manghera, et al.
Published: (2016-10-01)

TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex
by: Stephanie L. Rayner, et al.
Published: (2022-06-01)

Alterations in stress granule dynamics driven by TDP-43 and FUS: A link to pathological inclusions in ALS?
by: Anais eAulas, et al.
Published: (2015-10-01)

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
by: Rachel Atkinson, et al.
Published: (2021-02-01)