Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade

Abstract Pregnancy associated malaria (PAM) causes adverse pregnancy and birth outcomes owing to Plasmodium falciparum accumulation in the placenta. Placental accumulation is mediated by P. falciparum protein VAR2CSA, a leading PAM-specific vaccine target. The extent of its antigen diversity and imp...

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Bibliographic Details
Main Authors: Jaymin C. Patel, Nicholas J. Hathaway, Christian M. Parobek, Kyaw L. Thwai, Mwayiwawo Madanitsa, Carole Khairallah, Linda Kalilani-Phiri, Victor Mwapasa, Achille Massougbodji, Nadine Fievet, Jeffery A. Bailey, Feiko O. ter Kuile, Philippe Deloron, Stephanie M. Engel, Steve M. Taylor, Jonathan J. Juliano, Nicaise Tuikue Ndam, Steven R. Meshnick
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04737-y