Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells

Abstract BH3 mimetics are increasingly used as anti-cancer therapeutics either alone or in conjunction with other chemotherapies. However, mounting evidence has also demonstrated that BH3 mimetics modulate varied amounts of apoptotic signaling in healthy immune populations. In order to maximize thei...

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Bibliographic Details
Main Authors: Lindsey M. Ludwig, Katrina M. Hawley, David B. Banks, Anika T. Thomas-Toth, Bruce R. Blazar, Megan E. McNerney, Joel D. Leverson, James L. LaBelle
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04285-4