Investigation of Permeation of Theophylline through Skin Using Selected Piperazine-2,5-Diones

Investigation of Permeation of Theophylline through Skin Using Selected Piperazine-2,5-Diones

Transdermal administration of drugs that penetrate, in this case directly into the blood circulation, has many advantages and is promising for many drugs thanks to its easy application and good patient compliance. (<i>S</i>)-8-Methyl-6,9-diazaspiro[4.5]decan-7,10-dione (alaptide), has be...

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Bibliographic Details
Main Authors: Aneta Pokorna, Pavel Bobal, Michal Oravec, Lucie Rarova, Janette Bobalova, Josef Jampilek
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
piperazine-2,5-diones
theophylline
permeation
skin
Franz diffusion cell
HPLC determination
cytotoxicity
Online Access:https://www.mdpi.com/1420-3049/24/3/566

Internet

https://www.mdpi.com/1420-3049/24/3/566

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