B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma

B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma

Abstract Background Beta-1,3-galactosyltransferase-4 (B3GALT4) plays a critical regulatory role in tumor biology. However, the role of B3GALT4 in modulating the tumor microenvironment (TME) of neuroblastoma (NB) remains unknown. Methods Public datasets and clinical NB samples were collected to evalu...

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Bibliographic Details
Main Authors: Yong-Liang Sha, Yun Liu, Jia-Xing Yang, Yang-Yang Wang, Bao-Cheng Gong, Yan Jin, Tong-Yuan Qu, Fan-Tong Xia, Lei Han, Qiang Zhao
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ganglioside GD2
Lipid raft
Beta-1,3-galactosyltransferase-4
CD8+ T-cell chemokine
Immunotherapy
Neuroblastoma
Online Access:https://doi.org/10.1186/s13046-022-02523-x

Internet

https://doi.org/10.1186/s13046-022-02523-x

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