Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity

Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity

Fatty acid (FA)-stimulated insulin secretion (FASIS) is reviewed here in contrast to type 2 diabetes etiology, resulting from FA overload, oxidative stress, intermediate hyperinsulinemia, and inflammation, all converging into insulin resistance. Focusing on pancreatic islet β-cells, we comp...

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Bibliographic Details
Main Authors: Petr Ježek, Martin Jabůrek, Blanka Holendová, Lydie Plecitá-Hlavatá
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
fatty acids
fatty acid-stimulated insulin secretion
GPR40
pancreatic β-cells
oxidative stress
lipotoxicity
type 2 diabetes
low-grade inflammation
Online Access:http://www.mdpi.com/1420-3049/23/6/1483

Internet

http://www.mdpi.com/1420-3049/23/6/1483

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