Human Hepatic CD56bright NK Cells Display a Tissue-Resident Transcriptional Profile and Enhanced Ability to Kill Allogenic CD8+ T Cells

Human Hepatic CD56bright NK Cells Display a Tissue-Resident Transcriptional Profile and Enhanced Ability to Kill Allogenic CD8+ T Cells

Liver-resident CD56brightCD16- natural killer (NK) cells are enriched in the human liver and are phenotypically distinct from their blood counterparts. Although these cells are capable of rapid cytotoxic effector activity, their functional role remains unclear. We hypothesise that they may contribut...

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Bibliographic Details
Main Authors: Gráinne Jameson, Cathal Harmon, Rhyla Mae Santiago, Diarmaid D. Houlihan, Tom K. Gallagher, Lydia Lynch, Mark W. Robinson, Cliona O’Farrelly
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
NK cell
resident
CD8+ T cell
liver
transplant
tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.921212/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.921212/full

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