Hepatic SIRT6 deficit promotes liver tumorigenesis in the mice models

Hepatic SIRT6 deficit promotes liver tumorigenesis in the mice models

SIRT6 belongs to class III sirtuin family with NAD+-dependent histone deacetylase activities and controls multiple processes including aging, metabolism and inflammation. In recent years, increasing studies showed tumor suppressor role of SIRT6 in HCC development. We established a two-stage DEN foll...

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Bibliographic Details
Main Authors: Mei Wang, Linhua Lan, Fan Yang, Shan Jiang, Haojun Xu, Chengfei Zhang, Guoren Zhou, Hongping Xia, Jinglin Xia
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-05-01
Series:Genes and Diseases
Subjects:
ERK1/2 pathway
HCC
Liver carcinogenesis
Mouse model
SIRT6
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304220301124

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http://www.sciencedirect.com/science/article/pii/S2352304220301124

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