Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H<sub>2</sub>O<sub>2</sub>- and Aβ<sub>1-42</sub>-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H<sub>2</sub>O<sub>2</sub>- and Aβ<sub>1-42</sub>-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

With the lack of available drugs able to prevent the progression of Alzheimer&#8217;s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency. Here, we were inspired by the widely reported poten...

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Bibliographic Details
Main Authors: Ana M. de Matos, Alice Martins, Teresa Man, David Evans, Magnus Walter, Maria Conceição Oliveira, Óscar López, José G. Fernandez-Bolaños, Philipp Dätwyler, Beat Ernst, M. Paula Macedo, Marialessandra Contino, Nicola A. Colabufo, Amélia P. Rauter
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Pharmaceuticals
Subjects:
Alzheimer’s disease
Aβ<sub>1-42</sub>
cholinesterase inhibitors
flavones
chromen-4-ones
C-glucosyl flavonoids
PAMPA
Online Access:https://www.mdpi.com/1424-8247/12/2/98

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https://www.mdpi.com/1424-8247/12/2/98

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