Altered excitatory and inhibitory neocortical circuitry leads to increased convulsive severity after pentylenetetrazol injection in an animal model of schizencephaly, but not of microgyria

Altered excitatory and inhibitory neocortical circuitry leads to increased convulsive severity after pentylenetetrazol injection in an animal model of schizencephaly, but not of microgyria

Abstract Objective Malformations of the polymicrogyria spectrum can be mimicked in rodents through neonatal transcranial focal cortical freeze lesions. The animals presenting the malformations present both altered synaptic events and epileptiform activity in the vicinity of the microgyrus, but the c...

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Bibliographic Details
Main Authors: Luiza dosSantos Heringer, Julia Rios Carvalho, Julia Teixeira Oliveira, Bruna Texeira Silva, Domethila Mariano deSouza Aguiar dos Santos, Anna Lecticia Martinez Martinez Toledo, Laura Maria Borges Savoldi, Debora Magalhães Portela, Suelen Adriani Marques, Paula Campello Costa Lopes, Ana Maria Blanco Martinez, Henrique Rocha Mendonça
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Epilepsia Open
Subjects:
epilepsy
neuroplasticity
polymicrogyria
Schizencephaly
synaptogenesis
Online Access:https://doi.org/10.1002/epi4.12625

Internet

https://doi.org/10.1002/epi4.12625

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