Modification of Boc-Protected CAN508 via Acylation and Suzuki-Miyaura Coupling

Modification of Boc-Protected CAN508 via Acylation and Suzuki-Miyaura Coupling

The cyclin-dependent kinase inhibitor, CAN508, was protected with di-tert-butyl dicarbonate to access the amino-benzoylated pyrazoles. The bromo derivatives were further arylated by Suzuki-Miyaura coupling using the XPhos Pd G2 pre-catalyst. The coupling reaction provided generally the para-substitu...

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Bibliographic Details
Main Authors: Martin Pisár, Eva Schütznerová, Filip Hančík, Igor Popa, Zdeněk Trávníček, Petr Cankař
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Molecules
Subjects:
pyrazole
Boc-protection
Suzuki-Miyaura reaction
acylation
CDK inhibitor
XPhos Pd G2
Online Access:http://www.mdpi.com/1420-3049/23/1/149

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http://www.mdpi.com/1420-3049/23/1/149

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