Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice

Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice

Elevated plasma lipoprotein(a) (LPA) levels are recognized as an independent risk factor for cardiovascular diseases. Our knowledge on LPA metabolism is incomplete, which makes it difficult to develop LPA-lowering medications. Nicotinic acid (NA) is the main drug recommended for the treatment of pat...

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Bibliographic Details
Main Authors: Indumathi Chennamsetty, Karam M. Kostner, Thierry Claudel, Manjula Vinod, Sasa Frank, Thomas S. Weiss, Michael Trauner, Gerhard M. Kostner
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Journal of Lipid Research
Subjects:
primary human hepatocytes
reporter assay
apolipoprotein(a)
mRNA expression
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520412568

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http://www.sciencedirect.com/science/article/pii/S0022227520412568

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