Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

Human schistosomiasis is a disease which globally affects over 229 million people. Three major species affecting humans are Schistosoma mansoni, S. haematobium and S. japonicum. Previous treatment of S. mansoni includes the use of oxamniquine (OXA), a prodrug that is enzymatically activated in S. ma...

詳細記述

書誌詳細
主要な著者: Anastasia R. Rugel, Meghan A. Guzman, Alexander B. Taylor, Frédéric D. Chevalier, Reid S. Tarpley, Stanton F. McHardy, Xiaohang Cao, Stephen P. Holloway, Timothy J.C. Anderson, P. John Hart, Philip T. LoVerde
フォーマット: 論文
言語:English
出版事項: Elsevier 2020-08-01
シリーズ:International Journal for Parasitology: Drugs and Drug Resistance
主題:
Schistosoma spp.
Drug binding
Oxamniquine
Sulfotransferase
オンライン･アクセス:http://www.sciencedirect.com/science/article/pii/S2211320720300063

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http://www.sciencedirect.com/science/article/pii/S2211320720300063

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