Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

Human schistosomiasis is a disease which globally affects over 229 million people. Three major species affecting humans are Schistosoma mansoni, S. haematobium and S. japonicum. Previous treatment of S. mansoni includes the use of oxamniquine (OXA), a prodrug that is enzymatically activated in S. ma...

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Podrobná bibliografie
Hlavní autoři: Anastasia R. Rugel, Meghan A. Guzman, Alexander B. Taylor, Frédéric D. Chevalier, Reid S. Tarpley, Stanton F. McHardy, Xiaohang Cao, Stephen P. Holloway, Timothy J.C. Anderson, P. John Hart, Philip T. LoVerde
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2020-08-01
Edice:International Journal for Parasitology: Drugs and Drug Resistance
Témata:
Schistosoma spp.
Drug binding
Oxamniquine
Sulfotransferase
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2211320720300063

Internet

http://www.sciencedirect.com/science/article/pii/S2211320720300063

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