Cell-free and alkylated hemoproteins improve survival in mouse models of carbon monoxide poisoning

Cell-free and alkylated hemoproteins improve survival in mouse models of carbon monoxide poisoning

I.v. administration of a high-affinity carbon monoxide–binding (CO-binding) molecule, recombinant neuroglobin, can improve survival in CO poisoning mouse models. The current study aims to discover how biochemical variables of the scavenger determine the CO removal from the RBCs by evaluating 3 readi...

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Bibliographic Details
Main Authors: Qinzi Xu, Jason J. Rose, Xiukai Chen, Ling Wang, Anthony W. DeMartino, Matthew R. Dent, Sagarika Tiwari, Kaitlin Bocian, Xueyin N. Huang, Qin Tong, Charles F. McTiernan, Lanping Guo, Elmira Alipour, Trevor C. Jones, K. Burak Ucer, Daniel B. Kim-Shapiro, Jesús Tejero, Mark T. Gladwin
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-11-01
Series:JCI Insight
Subjects:
Pulmonology
Therapeutics
Online Access:https://doi.org/10.1172/jci.insight.153296

Internet

https://doi.org/10.1172/jci.insight.153296

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