Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma

Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma

Abstract Defects in homologous recombination repair (HRR) in tumors correlate with poor prognosis and metastases development. Determining HRR deficiency (HRD) is of major clinical relevance as it is associated with therapeutic vulnerabilities and remains poorly investigated in sarcoma. Here, we show...

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Bibliographic Details
Main Authors: Lara Planas‐Paz, Alicia Pliego‐Mendieta, Catherine Hagedorn, Domingo Aguilera‐Garcia, Martina Haberecker, Fabian Arnold, Marius Herzog, Lorenz Bankel, Roman Guggenberger, Sabrina Steiner, Yanjiang Chen, Abdullah Kahraman, Martin Zoche, Mark A Rubin, Holger Moch, Christian Britschgi, Chantal Pauli
Format: Article
Language:English
Published: Springer Nature 2023-04-01
Series:EMBO Molecular Medicine
Subjects:
genomic instability
HRDness
HRD score
sarcoma
Online Access:https://doi.org/10.15252/emmm.202216863

Internet

https://doi.org/10.15252/emmm.202216863

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