Human Stem Cell-Derived GABAergic Interneurons Establish Efferent Synapses onto Host Neurons in Rat Epileptic Hippocampus and Inhibit Spontaneous Recurrent Seizures

Human Stem Cell-Derived GABAergic Interneurons Establish Efferent Synapses onto Host Neurons in Rat Epileptic Hippocampus and Inhibit Spontaneous Recurrent Seizures

Epilepsy is a complex disorder affecting the central nervous system and is characterised by spontaneously recurring seizures (SRSs). Epileptic patients undergo symptomatic pharmacological treatments, however, in 30% of cases, they are ineffective, mostly in patients with temporal lobe epilepsy. Ther...

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Bibliographic Details
Main Authors: Eliška Waloschková, Ana Gonzalez-Ramos, Apostolos Mikroulis, Jan Kudláček, My Andersson, Marco Ledri, Merab Kokaia
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
human embryonic stem cells
GABA
interneurons
optogenetics
epilepsy
cell integration
Online Access:https://www.mdpi.com/1422-0067/22/24/13243

Internet

https://www.mdpi.com/1422-0067/22/24/13243

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