mGluR5 Negative Modulators for Fragile X: Treatment Resistance and Persistence

mGluR5 Negative Modulators for Fragile X: Treatment Resistance and Persistence

Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5) might be efficacious in treati...

Full description

Bibliographic Details
Main Authors: David C. Stoppel, Patrick K. McCamphill, Rebecca K. Senter, Arnold J. Heynen, Mark F. Bear
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Psychiatry
Subjects:
fragile X syndrome
FMRP
glycogen synthase kinase
acquired treatment resistance
drug tolerance
autism
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.718953/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2021.718953/full

Similar Items