Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.

Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucity of knowledge regarding the biology of T. congole...

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Main Authors: Pieter C Steketee, Emily A Dickie, James Iremonger, Kathryn Crouch, Edith Paxton, Siddharth Jayaraman, Omar A Alfituri, Georgina Awuah-Mensah, Ryan Ritchie, Achim Schnaufer, Tim Rowan, Harry P de Koning, Catarina Gadelha, Bill Wickstead, Michael P Barrett, Liam J Morrison
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009734