Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells

Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells

Abstract Background Chronic limb-threatening ischemia (CLTI), a severe manifestation of peripheral arterial disease (PAD), is associated with a 1-year limb amputation rate of approximately 15–20% and substantial mortality. A key feature of CLTI is the compromised regenerative ability of skeletal mus...

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Bibliographic Details
Main Authors: Kevin W. Southerland, Yueyuan Xu, Derek T. Peters, Xin Lin, Xiaolin Wei, Yu Xiang, Kaileen Fei, Lindsey A. Olivere, Jeremy M. Morowitz, James Otto, Qunsheng Dai, Christopher D. Kontos, Yarui Diao
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Genome Medicine
Subjects:
Peripheral arterial disease
Chronic limb-threatening ischemia
Single-cell transcriptome analysis
Murine hindlimb ischemia
Skeletal muscle regeneration
Muscle satellite cells
Online Access:https://doi.org/10.1186/s13073-023-01250-y

Internet

https://doi.org/10.1186/s13073-023-01250-y

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