Statins Induce Locomotion and Muscular Phenotypes in <i>Drosophila melanogaster</i> That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes

Statins Induce Locomotion and Muscular Phenotypes in <i>Drosophila melanogaster</i> That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes

The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this study, we employ <i>Drosophila melanogaster</i> to dissect possible underlying mechanisms for SIM. We observe that chronic fluvastatin treatment causes reduced general locomotion activity and climbin...

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Bibliografische gegevens
Hoofdauteurs: Mohamed H. Al-Sabri, Neha Behare, Ahmed M. Alsehli, Samuel Berkins, Aadeya Arora, Eirini Antoniou, Eleni I. Moysiadou, Sowmya Anantha-Krishnan, Patricia D. Cosmen, Johanna Vikner, Thiago C. Moulin, Nourhene Ammar, Hadi Boukhatmi, Laura E. Clemensson, Mathias Rask-Andersen, Jessica Mwinyi, Michael J. Williams, Robert Fredriksson, Helgi B. Schiöth
Formaat: Artikel
Taal:English
Gepubliceerd in: MDPI AG 2022-11-01
Reeks:Cells
Onderwerpen:
statins
fluvastatin
statin-induced myopathy
Hmgcr
skeletal muscle chloride channel
ClC-a
Online toegang:https://www.mdpi.com/2073-4409/11/22/3528

Internet

https://www.mdpi.com/2073-4409/11/22/3528

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