Molecular Docking, Drug-Likeness Analysis, In Silico Pharmacokinetics, and Toxicity Studies of p-Nitrophenyl Hydrazones as Anti-inflammatory Compounds against COX-2, 5-LOX, and H+/K+ ATPase

Molecular Docking, Drug-Likeness Analysis, In Silico Pharmacokinetics, and Toxicity Studies of p-Nitrophenyl Hydrazones as Anti-inflammatory Compounds against COX-2, 5-LOX, and H+/K+ ATPase

Nonsteroidal anti-inflammatory drugs (NSAIDs) and coxibs are traditional medicines for the treatment of inflammation, yet associated with serious side effects. Hence, the need for discovering novel compounds with valuable clinical benefits is of great importance. In this study, 18 derivatives of p-n...

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Bibliographic Details
Main Authors: Sodeeq Babalola, Nosakhare Igie, Isaiah Odeyemi
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2022-12-01
Series:Pharmaceutical Fronts
Subjects:
p-nitrophenyl hydrazones
anti-inflammatory
molecular docking
docking simulation
pharmacokinetics
drug-likeness
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1759688

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1759688

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