Comparison of the mechanisms of estrogen disrupting effects between triphenyl phosphate (TPhP) and tris(1,3-dichloro-2-propyl) phosphate (TDCIPP)

Comparison of the mechanisms of estrogen disrupting effects between triphenyl phosphate (TPhP) and tris(1,3-dichloro-2-propyl) phosphate (TDCIPP)

As the typical aryl-organophosphate flame retardants (OPFRs), triphenyl phosphate (TPhP) and tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) were reported to be estrogen disruptors. However, estrogen receptor α (ERα) binding experiments could not explain their biological effects. In this study, their...

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Bibliographic Details
Main Authors: Xiaoya Ji, Na Li, Mei Ma, Xinyan Li, Kongrui Zhu, Kaifeng Rao, Zijian Wang, Jingfeng Wang, Yanjun Fang
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Triphenyl phosphate (TPhP)
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP)
Estrogen disrupting effects
Estrogen receptor α (ERα)
G protein-coupled estrogen receptor (GPER)
Estrogen biosynthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321011817

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http://www.sciencedirect.com/science/article/pii/S0147651321011817

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