Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls

Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls

Abstract Background Insulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of central precocious puberty (CPP). Methods We assessed single nucleotid...

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Bibliographic Details
Main Authors: Hua-Pin Chang, Shun-Fa Yang, Shu-Li Wang, Pen-Hua Su
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Endocrine Disorders
Subjects:
Insulin-like growth factor 1
Insulin-like growth factor 2
Central precocious puberty
Single nucleotide polymorphism
Insulin-like growth factor binding protein 3
Insulin-like growth factor receptor
Online Access:http://link.springer.com/article/10.1186/s12902-018-0271-1

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http://link.springer.com/article/10.1186/s12902-018-0271-1

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