Use of Farnesyl Transferase Inhibitors in an Ageing Model in <i>Drosophila</i>
The presence of farnesylated proteins at the inner nuclear membrane (INM), such as the Lamins or Kugelkern in <i>Drosophila</i>, leads to specific changes in the nuclear morphology and accelerated ageing on the organismal level reminiscent of the Hutchinson–Gilford progeria syndrome (HGP...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Series: | Journal of Developmental Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2221-3759/11/4/40 |