Use of Farnesyl Transferase Inhibitors in an Ageing Model in <i>Drosophila</i>

Use of Farnesyl Transferase Inhibitors in an Ageing Model in <i>Drosophila</i>

The presence of farnesylated proteins at the inner nuclear membrane (INM), such as the Lamins or Kugelkern in <i>Drosophila</i>, leads to specific changes in the nuclear morphology and accelerated ageing on the organismal level reminiscent of the Hutchinson–Gilford progeria syndrome (HGP...

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Bibliographic Details
Main Authors: Annely Brandt, Roman Petrovsky, Maria Kriebel, Jörg Großhans
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Journal of Developmental Biology
Subjects:
HGPS
<i>Drosophila</i>
farnesyl transferase inhibitor
ABT-100
nuclear envelope
lamin
Online Access:https://www.mdpi.com/2221-3759/11/4/40

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