TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors

TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors

Summary: The molecular mechanism underlying the functional interaction between H1R and TRPV1 remains unclear. We show here that H1R directly binds to the carboxy-terminal region of TRPV1 at residues 715–725 and 736–749. Cell-penetrating peptides containing these sequences suppress histamine-induced...

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Bibliographic Details
Main Authors: Yingwei Gao, Ruining Ma, Weiji Weng, Heng Zhang, Yingping Wang, Rongjun Guo, Xiaokun Gu, Yang Yang, Fan Yang, Aiwu Zhou, Jinke Cheng, Zhe-Yu Chen, Michael X. Zhu, Yong Li
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722007586

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http://www.sciencedirect.com/science/article/pii/S2211124722007586

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