WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin

WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin

Summary: Transcription-replication (T-R) conflicts cause replication stress and loss of genome integrity. However, the transcription-related processes that restrain such conflicts are poorly understood. Here, we demonstrate that the RNA polymerase II (RNAPII) C-terminal domain (CTD) phosphatase prot...

Full description

Bibliographic Details
Main Authors: Helga B. Landsverk, Lise E. Sandquist, Lilli T.E. Bay, Barbara Steurer, Coen Campsteijn, Ole J.B. Landsverk, Jurgen A. Marteijn, Eva Petermann, Laura Trinkle-Mulcahy, Randi G. Syljuåsen
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
Transcription-replication conflicts
Replication stress
PP1 phosphatase
PNUTS
WDR82
RNA polymerase II
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314583

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720314583

Similar Items