Pharmacokinetics and efficacy of topical inserts containing tenofovir alafenamide fumarate and elvitegravir administered rectally in macaquesResearch in context

Pharmacokinetics and efficacy of topical inserts containing tenofovir alafenamide fumarate and elvitegravir administered rectally in macaquesResearch in context

Summary: Background: Topical on-demand forms for HIV pre-exposure prophylaxis (PrEP) may be a desirable alternative for people that prefer not to use daily PrEP. CONRAD has developed inserts containing tenofovir alafenamide (TAF) and elvitegravir (EVG) for on-demand vaginal or rectal pericoital use...

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Bibliographic Details
Main Authors: Natalia Makarova, Tyana Singletary, M. Melissa Peet, James Mitchell, Angela Holder, Chuong Dinh, Vivek Agrahari, Maria Mendoza, Yi Pan, Walid Heneine, Meredith R. Clark, J. Gerardo García-Lerma, James M. Smith, Gustavo F. Doncel
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:EBioMedicine
Subjects:
HIV pre-exposure prophylaxis
Macaque models
Topical PrEP
Tenofovir alafenamide
Elvitegravir
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422005205

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http://www.sciencedirect.com/science/article/pii/S2352396422005205

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