The Thioredoxin System is Regulated by the ASK-1/JNK/p38/Survivin Pathway During Germ Cell Apoptosis

The Thioredoxin System is Regulated by the ASK-1/JNK/p38/Survivin Pathway During Germ Cell Apoptosis

The aim is to explore the mechanism of the apoptosis signal-regulating kinase-1 (ASK-1) signaling pathway and the involvement of the thioredoxin (Trx) system during testicular ischemia reperfusion injury (tIRI) by using ASK-1 specific inhibitor, NQDI-1. Male Sprague-Dawley rats (n = 36, 250&#872...

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Bibliographic Details
Main Authors: Nora Al-Kandari, Fatemah Fadel, Farah Al-Saleh, Farah Khashab, May Al-Maghrebi
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
germ cell apoptosis
testicular ischemia reperfusion injury
oxidative DNA damage
thioredoxin
survivin
ASK-1
JNK
NQDI-1
Online Access:https://www.mdpi.com/1420-3049/24/18/3333

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https://www.mdpi.com/1420-3049/24/18/3333

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