Allosteric Binding Sites of Aβ Peptides on the Acetylcholine Synthesizing Enzyme ChAT as Deduced by In Silico Molecular Modeling

Allosteric Binding Sites of Aβ Peptides on the Acetylcholine Synthesizing Enzyme ChAT as Deduced by In Silico Molecular Modeling

The native function of amyloid-β (Aβ) peptides is still unexplored. However, several recent reports suggest a prominent role of Aβ peptides in acetylcholine homeostasis. To clarify this role of Aβ, we have reported that Aβ peptides at physiological concentrations can directly enhance the catalytic e...

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Bibliographic Details
Main Authors: Anurag TK Baidya, Amit Kumar, Rajnish Kumar, Taher Darreh-Shori
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
β-amyloid
choline acetyltransferase
cholinergic system
Alzheimer’s disease
in silico modeling
Online Access:https://www.mdpi.com/1422-0067/23/11/6073

Internet

https://www.mdpi.com/1422-0067/23/11/6073

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