TNFa and IL-2 armed adenoviruses enable complete responses by anti-PD-1 checkpoint blockade

TNFa and IL-2 armed adenoviruses enable complete responses by anti-PD-1 checkpoint blockade

Releasing the patient's immune system against their own malignancy by the use of checkpoint inhibitors is delivering promising results. However, only a subset of patients currently benefit from them. One major limitation of these therapies relates to the inability of T cells to detect or penetr...

Full description

Bibliographic Details
Main Authors: V. Cervera-Carrascon, M. Siurala, J. M. Santos, R. Havunen, S. Tähtinen, P. Karell, S. Sorsa, A. Kanerva, A. Hemminki
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:OncoImmunology
Subjects:
immunotherapy
virotherapy
immunovirotherapy
checkpoint blockade
adoptive cell therapy
adenovirus
melanoma
solid tumors
anti-pd1
t cell therapy
adoptive t cell therapies
models of immunostimulation
therapeutic antibodies
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1412902

Internet

http://dx.doi.org/10.1080/2162402X.2017.1412902

Similar Items