Potassium channel-based optogenetic silencing

Potassium channel-based optogenetic silencing

Optogenetic tools enable precise experimental control of the behaviour of cells. Here, the authors introduce a genetically-encoded two-protein system that enables silencing of excitable cells such as neurons and cardiomyocytes using blue light, and demonstrate its utility both in vitro and In vivo.

Bibliographic Details
Main Authors: Yinth Andrea Bernal Sierra, Benjamin R. Rost, Martin Pofahl, António Miguel Fernandes, Ramona A. Kopton, Sylvain Moser, Dominik Holtkamp, Nicola Masala, Prateep Beed, John J. Tukker, Silvia Oldani, Wolfgang Bönigk, Peter Kohl, Herwig Baier, Franziska Schneider-Warme, Peter Hegemann, Heinz Beck, Reinhard Seifert, Dietmar Schmitz
Format: Article
Language:English
Published: Nature Portfolio 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07038-8

Internet

https://doi.org/10.1038/s41467-018-07038-8

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